Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD
Interview with John H. Krystal, MD, author of Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD
Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage
Interview with J. Michael McWilliams, MD, Phd, author of Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage
Interventions for War-Related Posttraumatic Stress Disorder: Meeting Veterans Where They Are
Interview with Charles Hoge, MD, author of Interventions for War-Related Posttraumatic Stress Disorder: Meeting Veterans Where They Are
Prevention of Melanoma With Regular Sunscreen Use
Interview with June K. Robinson, MD, author of Prevention of Melanoma With Regular Sunscreen Use
Application of Electronic Health Records to the Joint Commission's 2011 National Patient Safety Goals
Interview with Ryan Radecki, MD, author of Application of Electronic Health Records to the Joint Commission's 2011 National Patient Safety Goals
Improving Postdischarge Outcomes in Patients Hospitalized for Acute Heart Failure Syndromes
Interview with Mihai Gheorghiade, MD, author of Improving Postdischarge Outcomes in Patients Hospitalized for Acute Heart Failure Syndromes
A New Frontier in Patient Safety
Interview with Don Berwick, MD, author of A New Frontier in Patient Safety
From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep
Interview with Benjamin Djulbegovic, MD, PhD, author of From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep
Patient-Physican Communication: It's About Time
Interview with Wendy Levinson, MD, author of Patient-Physican Communication: It's About Time
How to Enroll Participants in Research Ethically
Interview with David Wendler, PhD, author of How to Enroll Participants in Research Ethically
Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment
Interview with Nora D. Volkow, MD, author of Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment
Physician Communication in the 21st Century
Interview with Allan S. Detsky, MD, PhD, author of Physician Communication in the 21st Century
Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries
Interview with Lawrence O. Gostin, JD, author of Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries
Damage Prevention and Control for Financial Incapacity
Interview with Charles Sabatino, JD, author of Damage Prevention and Control for Financial Incapacity
A Physician Management Infrastructure
Interview with Peter J. Pronovost, MD, PhD, author of A Physician Management Infrastructure
A Vision for Patient-Centered Health Information Systems
Interview with Alex H. Krist, MD, MPH, author of A Vision for Patient-Centered Health Information Systems
Re"evolutionary" Regenerative Medicine
Interview with Helen M. Blau, PhD, author of Re"evolutionary" Regenerative Medicine
he United States' Engagement in Global Tobacco Control
Interview with Lawrence O. Gostin, JD, author of The United States' Engagement in Global Tobacco Control
Active Surveillance for Prostate Cancer
Interview with Ian M. Thompson, MD, author of Active Surveillance for Prostate Cancer
Discussing Radiation Risks Associated With CT Scans With Patients
Interview with Mark Otto Baerlocher, MD, author of Discussing Radiation Risks Associated With CT Scans With Patients
Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making
Interview with Daniel P. Sulmasy, MD, PhD, author of Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making
Putting the Public Back in Public Reporting of Health Care Quality
Interview with Tara Lagu, MD, MPH, author of Putting the Public Back in Public Reporting of Health Care Quality
What If Physicians Actually Had to Control Medical Costs?
Interview with Robert H. Brook, MD, ScD, author of What If Physicians Actually Had to Control Medical Costs?
Understanding Depression and Distress Among Medical Students
Interview with Laura Weiss Roberts, MD, MA, author of Understanding Depression and Distress Among Medical Students
Societal Perceptions of Physicians: Knights, Knaves, or Pawns?
Interview with Sachin H. Jain, MD, MBA and Christine K. Cassel, MD, authors of Societal Perceptions of Physicians: Knights, Knaves, or Pawns?
Adjunctive vitamin A and D during pulmonary tuberculosis treatment: a randomized controlled trial with a 2×2 factorial design
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02751C, Paper
DOI: 10.1039/C9FO02751C, Paper
Jinyu Wang, Ke Xiong, Qiuzhen Wang, Shanliang Zhao, Yufeng Liu, Aiguo Ma
Background and objective: Vitamin A and D have immunoregulatory effects and may improve the response to pulmonary tuberculosis treatment. The interaction of vitamin A and D on pulmonary tuberculosis treatment...
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Background and objective: Vitamin A and D have immunoregulatory effects and may improve the response to pulmonary tuberculosis treatment. The interaction of vitamin A and D on pulmonary tuberculosis treatment...
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Protective effects of Bifidobacterium adolescentis on collagen-induced arthritis in rats depend on timing of administration
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00077A, Paper
DOI: 10.1039/D0FO00077A, Paper
Zhexin Fan, Bo Yang, R. Paul Ross, Catherine Stanton, Guoxun Shi, Jianxin Zhao, Hao Zhang, Wei Chen
Early probiotics adminitration is a key timing to alleviate inflammation in rats with arthritis.
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Early probiotics adminitration is a key timing to alleviate inflammation in rats with arthritis.
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Unsaturated alginate oligosaccharides attenuated obesity-related metabolic abnormalities by modulating gut microbiota in high-fat-diet mice
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02857A, Paper
DOI: 10.1039/C9FO02857A, Paper
Shangyong Li, Linna Wang, Bo Liu, Ningning He
Gut microbiota plays an important role in the high-fat diet (HFD)-induced obesity and related metabolic syndrome (MetS). Our previous study has demonstrated that unsaturated alginate oligosaccharides (UAOS) degraded by alginate...
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Gut microbiota plays an important role in the high-fat diet (HFD)-induced obesity and related metabolic syndrome (MetS). Our previous study has demonstrated that unsaturated alginate oligosaccharides (UAOS) degraded by alginate...
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Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00711K, Paper
DOI: 10.1039/D0FO00711K, Paper
J. Q. Ma, Yun-Zhi Sun, Qing-Lei Ming, Zhi-Kai Tian, Yu-Jia Zhang, Chan-Min Liu
Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential renoprotective properties. Here we examined the protective effects of GAS against carbon tetrachloride (CCl4)-induced kidney inflammation and...
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Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential renoprotective properties. Here we examined the protective effects of GAS against carbon tetrachloride (CCl4)-induced kidney inflammation and...
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Polysaccharides from Enteromorpha prolifera protect against carbon tetrachloride-induced acute liver injury in mice via activation of Nrf2/HO-1 signaling, and suppression of oxidative stress, inflammation and apoptosis
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00575D, Paper
DOI: 10.1039/D0FO00575D, Paper
Fuchuan Guo, Xinyun Zhuang, Mengyuan Han, Wenting Lin
EPP protected against hepatic injury induced by CCl4-derived reactive intermediates through the suppression of hepatic oxidative stress, inflammation, and apoptosis.
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EPP protected against hepatic injury induced by CCl4-derived reactive intermediates through the suppression of hepatic oxidative stress, inflammation, and apoptosis.
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Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo
Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02521A, Paper
DOI: 10.1039/C9FO02521A, Paper
Huahong Yang, Cong Hua, Xiaolin Yang, Xiaoye Fan, Hongyu Song, Liping Peng, Xinxin Ci
Schematic model of the protective effects by Pts on LPS-induced lung fibrosis.
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Schematic model of the protective effects by Pts on LPS-induced lung fibrosis.
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The milk macromolecular peptide: preparation and evaluation of antihypertensive activity in rats
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00151A, Paper
DOI: 10.1039/D0FO00151A, Paper
Pengfei Cui, Xue Yang, Yunliang Li, Qiufang Liang, Yucheng Wang, Feng Lu, John Owusu, Shanfen Huang, Xiaofeng Ren, Haile Ma
In order to avoid the discomfort of digesting milk protein and make full use of the gastrointestinal digestive function, a milk macromolecular peptide was prepared with ACE inhibitory activity after gastrointestinal digestion as the index.
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In order to avoid the discomfort of digesting milk protein and make full use of the gastrointestinal digestive function, a milk macromolecular peptide was prepared with ACE inhibitory activity after gastrointestinal digestion as the index.
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Deciphering calcium-binding behaviors of casein phosphopeptides by experimental approaches and molecular simulation
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00844C, Paper
DOI: 10.1039/D0FO00844C, Paper
Minna Luo, Jie Xiao, Shengwei Sun, Fengchao Cui, Wei Li, Guo Liu, Yunqi Li, Yong Cao
Although specific groups in casein phosphopeptides (CPPs) have been identified to be essential for the calcium-binding capacity, how calcium binds with CPPs remains unclear. In the present study, experimental methods...
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Although specific groups in casein phosphopeptides (CPPs) have been identified to be essential for the calcium-binding capacity, how calcium binds with CPPs remains unclear. In the present study, experimental methods...
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Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00271B, Paper
DOI: 10.1039/D0FO00271B, Paper
Isabella Supardi Parida, Soo Takasu, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Toshiyuki Kimura, Takahiro Eitsuka, Kiyotaka Nakagawa
Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder in high-fat diet restored adiposity, glucose tolerance and insulin sensitivity in mice.
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Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder in high-fat diet restored adiposity, glucose tolerance and insulin sensitivity in mice.
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Influences of dietary starch structure on intestinal morphology, barrier functions, and epithelium apoptosis in weaned pigs
Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02652E, Paper
DOI: 10.1039/C9FO02652E, Paper
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Xiaoqian Gao, Bing Yu, Jie Yu, Xiangbing Mao, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Ping Zheng, Jun He, Daiwen Chen
The objective of the present study was to evaluate the effects of dietary starch structure on intestinal health of weaned pigs by determining the intestinal morphology, barrier functions, epithelium apoptosis and digestive enzymes.
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The objective of the present study was to evaluate the effects of dietary starch structure on intestinal health of weaned pigs by determining the intestinal morphology, barrier functions, epithelium apoptosis and digestive enzymes.
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The role of extensional rheology in the oral phase of swallowing: an in vitro study
Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02327E, Paper
DOI: 10.1039/C9FO02327E, Paper
Marco Marconati, Marco Ramaioli
In vitro swallowing experiments suggest that thin, viscoelastic liquids with strong apparent extensional viscosity lead to fast transit, lower oral residues and a compact bolus leaving the oral cavity.
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In vitro swallowing experiments suggest that thin, viscoelastic liquids with strong apparent extensional viscosity lead to fast transit, lower oral residues and a compact bolus leaving the oral cavity.
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Dietary supplementation of L-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00019A, Paper
DOI: 10.1039/D0FO00019A, Paper
Hao Zhang, Yi Ma, Mengzhi Wang, Mabrouk Elsabagh, Juan J. Loor, Hongrong Wang
The work aimed at investigating the effects of N-carbamylglutamate (NCG) or L-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).
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The work aimed at investigating the effects of N-carbamylglutamate (NCG) or L-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).
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Pedro Ximenez sun-dried grape must: a dietary supplement for a healthy longevity
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00204F, Paper
DOI: 10.1039/D0FO00204F, Paper
Noelia Morales-Prieto, Paula V. Huertas-Abril, Nieves López de Lerma, Isabel. L. Pacheco, José Pérez, Rafael Peinado, Nieves Abril
Sun-dried Pedro Ximénez white grapes must (PXM) is a potent antioxidant that regularizes apoptosis, proliferation, and regeneration of the structure and the function of aged mice liver. PXM consumption contributes to a healthy aging process.
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Sun-dried Pedro Ximénez white grapes must (PXM) is a potent antioxidant that regularizes apoptosis, proliferation, and regeneration of the structure and the function of aged mice liver. PXM consumption contributes to a healthy aging process.
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Mechanisms for Lactobacillus rhamnosus treatment of intestinal infection by drug-resistant Escherichia coli
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00128G, Paper
DOI: 10.1039/D0FO00128G, Paper
Na Li, Bing Pang, Junjun Li, Guanwen Liu, Xiaoguang Xu, Dongyan Shao, Chunmei Jiang, Baowei Yang, Junling Shi
Reducing the viability of pathogens may also play an important role for the therapeutic effects of Lactobacillus rhamnosus SHA113 against multiple-drug-resistant E. coli, as well as influencing on the intestinal integrity and functions of animals.
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Reducing the viability of pathogens may also play an important role for the therapeutic effects of Lactobacillus rhamnosus SHA113 against multiple-drug-resistant E. coli, as well as influencing on the intestinal integrity and functions of animals.
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Evaluation of Tenebrio molitor protein as a source of peptides for modulating physiological processes
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00734J, Paper
DOI: 10.1039/D0FO00734J, Paper
Fernando Rivero Pino, Raúl Pérez Gálvez, F. Javier Espejo Carpio, Emilia M. Guadix
Tenebrio molitor hydrolysates produced with commercial proteases showed improved ACE inhibitory and antioxidant properties. This source could be employed as functional ingredient in food preparations.
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Tenebrio molitor hydrolysates produced with commercial proteases showed improved ACE inhibitory and antioxidant properties. This source could be employed as functional ingredient in food preparations.
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Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway
Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02602A, Paper
DOI: 10.1039/C9FO02602A, Paper
Chu-Wen Li, Min-Zhen Deng, Zhi-Jie Gao, Yuan-Ye Dang, Guo-Dong Zheng, Xiu-Juan Yang, Ying-Xin Chao, Ye-Feng Cai, Xiao-Li Wu
The metabolite of ginsenosides, compound K improves memory and cognitive dysfunction in diabetes mellitus mice.
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The metabolite of ginsenosides, compound K improves memory and cognitive dysfunction in diabetes mellitus mice.
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Unveiling the bioactivity potential of Allium triquetrum L. lipophilic fraction: chemical characterization and in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00769B, Paper
DOI: 10.1039/D0FO00769B, Paper
Samia Rabah, Kahina Kouachi, Patricia Ramos, Ana T. P. C. Gomes, Adelaide Almeida, Hayate Haddadi-Guemghar, Khodir Madani, Armando Silvestre, Sónia A. O. Santos
The lipophilic composition of Allium triquetrum L. bulbs, flowers and leaves was studied for the first time, by GC-MS. Sixty-two compounds were firstly identified in A. triquetrum L. Fatty acids...
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The lipophilic composition of Allium triquetrum L. bulbs, flowers and leaves was studied for the first time, by GC-MS. Sixty-two compounds were firstly identified in A. triquetrum L. Fatty acids...
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Hypoglycemic effects and modulation of gut microbiota of diabetic mice by saponin from Polygonatum sibiricum
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00428F, Paper
DOI: 10.1039/D0FO00428F, Paper
Jiayuan Luo, Yangyang Chai, Min Zhao, Qingqi Guo, Yihong Bao
Polygonatum sibiricum is a medicinal and homologous plant grown in China. The saponin in Polygonatum sibiricum has shown its good hypoglycemic performance, and it can be developed as functional foods and drugs with hypoglycemic effect.
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Polygonatum sibiricum is a medicinal and homologous plant grown in China. The saponin in Polygonatum sibiricum has shown its good hypoglycemic performance, and it can be developed as functional foods and drugs with hypoglycemic effect.
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Kinetic profile and urinary excretion of phenyl-γ-valerolactones upon consumption of cranberry: a dose-response relationship
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00806K, Paper
DOI: 10.1039/D0FO00806K, Paper
Claudia Favari, Pedro Mena, Claudio Curti, Geoffrey Istas, Christian Heiss , Daniele Del Rio, Ana Rodriguez-Mateos
Cranberries are a rich source of poly(phenols), mainly monomeric and oligomeric flavan-3-ols. However, information on the appearance of their main circulating microbial metabolites, namely phenyl-γ-valerolactones and phenylvaleric acid, is lacking...
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Cranberries are a rich source of poly(phenols), mainly monomeric and oligomeric flavan-3-ols. However, information on the appearance of their main circulating microbial metabolites, namely phenyl-γ-valerolactones and phenylvaleric acid, is lacking...
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Cerebral effect of optimized Allium sativum oil-loaded chitosan nanorods: GC-MS analysis and in-vitro/in-vivo evaluation
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02911G, Paper
DOI: 10.1039/C9FO02911G, Paper
Rabab Kamel, Abeer Salama, Nesma Mohammed, Nermine Shaffie
The chemical constituents of Allium sativum (Garlic) oil were investigated using GC/Ms technique after silylation, and revealed the presence of several fatty acids and their esters. The most dominant was...
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The chemical constituents of Allium sativum (Garlic) oil were investigated using GC/Ms technique after silylation, and revealed the presence of several fatty acids and their esters. The most dominant was...
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Lactobacillus fermentum CECT5716 prevents renal damage in NZBWF1 mice model of systemic lupus erythematosus
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00578A, Paper
DOI: 10.1039/D0FO00578A, Paper
Néstor de la Visitación, Iñaki Robles-Vera, Marta Toral, Francisco O’Valle, Javier Moleon, Manuel Gómez-Guzmán, Miguel Romero, Marcos Duarte, Manuel Sanchez, Rosario Jimenez, Juan Duarte
The aim of this work was to evaluate whether the immune-modulatory bacteria Lactobacillus fermentum CECT5716 (LC40) protects kidneys in a female mouse model of lupus with hypertension. Twenty-week-old NZBWF1 (lupus)...
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The aim of this work was to evaluate whether the immune-modulatory bacteria Lactobacillus fermentum CECT5716 (LC40) protects kidneys in a female mouse model of lupus with hypertension. Twenty-week-old NZBWF1 (lupus)...
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Sugar matters: sugar moieties as reactivity-tuning factors in quercetin O-glycosides
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00319K, Paper
DOI: 10.1039/D0FO00319K, Paper
Cezara Zagrean-Tuza, Augustin C Moţ, Tomasz Chmiel, Attila Bende, Ioan Turcu
Quercetin, one of the most abundant flavonoids in plant-based foods, commonly occurs in nature in various glycosylated forms. There is still a less explored aspect regarding the cause of its...
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Quercetin, one of the most abundant flavonoids in plant-based foods, commonly occurs in nature in various glycosylated forms. There is still a less explored aspect regarding the cause of its...
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The Ameliorative Effect of Lactobacillus plantarum-12 on DSS-induced murine colitis
Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00007H, Paper
DOI: 10.1039/D0FO00007H, Paper
MengYing Sun, YuJun Liu, Yinglong Song, Yuan Gao, Fujunzhu Zhao, Yanghe Luo, Fang Qian, Guangqing Mu, Yanfeng Tuo
Some lactobacilli strains can exert beneficial effects on host when ingested in an adequate dose, such as immunoregulation and anti-inflammatory activities. In this study, the survival abilities in simulated gastrointestinal...
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Some lactobacilli strains can exert beneficial effects on host when ingested in an adequate dose, such as immunoregulation and anti-inflammatory activities. In this study, the survival abilities in simulated gastrointestinal...
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Jiaogulan tea (Gpostemma pentaphyllum) potentiates the antidiabetic effect of white tea via the AMPK and PI3K pathways in C57BL/6 mice
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00395F, Paper
DOI: 10.1039/D0FO00395F, Paper
Xiaoyan Xia, Jing Xu, Xude Wang, Hua Wang, Zhenchuan Lin, Keping Shao, LinLin Fang, Chenning Zhang, Yuqing Zhao
The use of plant-based beverages to interfere with the onset of diabetes may be a promising approach towards type 2 diabetes mellitus (T2DM).
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The use of plant-based beverages to interfere with the onset of diabetes may be a promising approach towards type 2 diabetes mellitus (T2DM).
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Enzyme reaction-guided identification of active components from the flowers of Sophora japonica var. violacea
Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00625D, Paper
DOI: 10.1039/D0FO00625D, Paper
Yunci Zhang, Dongyu Gu, Shuai He, Jing Meng, Jifeng Wang, Yunxiao Wang, Yi Wang, Jing Tian, Yi Yang
The flower of S. japonica is a favorite food and used as traditional medicine.
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The flower of S. japonica is a favorite food and used as traditional medicine.
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